Cytosolic phospholipase
WebMar 1, 2014 · Here, we show that cytosolic phospholipase A 2 ε (cPLA 2 ε, also known as PLA2G4E) is targeted to the membrane compartments of the clathrin-independent endocytic route through a C-terminal stretch of positively charged amino acids, which allows the enzyme to interact with phosphoinositide lipids [especially PI (4,5)P 2] that are enriched … National Center for Biotechnology Information
Cytosolic phospholipase
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WebDec 1, 1997 · Phospholipase A2 (PLA2) comprises a superfamily of enzymes that hydrolyse the ester bond of phospholipids at the sn-2 position1,2,3. Among the members of this superfamily, cytosolic PLA2 has ... WebPhospholipase a2 activity. Specific Function. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Pfam Domain Function.
WebMar 12, 2024 · PLA2G4A encodes for the cytosolic phospholipase A2α (cPLA2α), which is the rate-limiting enzyme in phospholipid metabolism and plays an important role during … WebApr 16, 2024 · Calcium-dependent cytosolic phospholipase A 2 (cPLA2) releases arachidonic acid (AA, 20:4 n-6), which plays important functions in storing energy, as a second messenger in neurotransmission, and as the precursor of eicosanoids [ 4, 5 ].
WebMar 7, 2024 · Molecular dynamics simulations revealed the optimal phospholipid binding mode leading to a detailed understanding of the preference of cytosolic phospholipase … WebCytosolic gIVaPLA2is a critical enzyme in the generation of arachidonate metabolites and in induction of β2-integrin adhesion in granulocytes. We hypothesized that …
WebSep 7, 2010 · Cytosolic phospholipase A2 (cPLA 2) is an enzyme that is responsible for the hydrolysis of membrane phospholipids such as phosphatidylcholine. Following …
WebApr 16, 2024 · Background Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease … small solar powered electric fence kitWeb• Cytosolic phospholipase A 2 inhibitors might be useful for topical application against diseases such as atopic dermatitis or psoriasis. • Secreted phospholipase A 2 inhibitors varespladib and varespladib methyl are currently studied for … small solar powered christmas treeWebMar 29, 2012 · Anti-Cytosolic Phospholipase A2 antibody (ab73406) at 1 µg/ml + HeLa Whole Cell Lysate - Bleomycin Treated (40U/ml) at 10 µg Secondary Goat polyclonal to … small solar powered air pumpWebHuman platelets pretreated with indomethacin release arachidonic acid predominantly through the activity of cytosolic phospholipase A2 (cPLA2), an 85-kDa protein. This enzyme is regulated by an increase in … highway 2 edmontonWebNov 21, 2014 · Cytosolic Phospholipase A2 Assay Kit (ab133090) can be used to determine the activity of cytosolic Phospholipase A2 (cPLA2) in purified … highway 2 family dinerWebMar 28, 2024 · These observations suggest that cytosolic Tli is required for the activation and/or export of Tle. We show that Tle growth inhibition activity remains Tli-dependent when phospholipase delivery into target bacteria is ensured through fusion to the VgrG β-spike protein. Together, these findings indicate that Tli has distinct functions depending ... small solar powered stick on lightWebJun 1, 2024 · Cytosolic phospholipase A 2 (PLA2G4) family comprises six members, cPLA 2 α, cPLA 2 β, cPLA 2 γ, cPLA 2 δ, cPLA 2 ε, and cPLA 2 ζ (Fig. 2). These … highway 2 east to west