WebApr 3, 2024 · Paradoxically, we found that chronic alcohol use increases intestinal goblet cell (GC) 54 number and mucin production in patients and mice. This, however, comes with the expense of 55 GC associated antigen passages (GAPs) closure and defective delivery of luminal antigens and 56 bacteria to lamina propria (LP) antigen presenting cells … WebDec 9, 2024 · Goblet cell associated antigen passages support the induction and maintenance of oral tolerance. Pabst, O. & Mowat, A. M. Oral tolerance to food protein. Mucosal Immunol. 5, 232–239 (2012). Bogunovic, M. et al. Origin of the lamina propria … We would like to show you a description here but the site won’t allow us.
EVALUATING THE ROLE OF GOBLET CELL ASSOCIATED ANTIGEN PASSAGES …
WebNov 1, 2024 · Recently it was appreciated that GCs can form goblet cell-associated antigen passages (GAPs) and deliver luminal substances to underlying lamina propria (LP) antigen-presenting cells (APCs) in a manner capable of inducing adaptive immune responses. GCs at other mucosal surfaces share characteristics with the GAP forming … WebFeb 1, 2024 · Goblet cell-associated antigen passages (GAPs), located in the small intestine and colon, deliver intraluminal antigens to antigen-presenting dendritic cells in the submucosa. This mechanism serves as an important step in the development and maintenance of tolerogenic dendritic cell populations expressing receptors to luminal … upcoming shows in us
Jenny GUSTAFSSON Principal Investigator PhD University of ...
WebThe goblet cell-associated antigen passages (GAPs), formed in the intestine and conjunctiva, contribute to immune responses by delivering antigens to immune … WebMar 15, 2012 · Using a minimally disruptive in vivo imaging approach we show that in the steady state, small intestine goblet cells (GCs) function as passages delivering low molecular weight soluble antigens ... rectangular rubber feet for garden furniture