WebObjectives: Published cases of oral high-grade neuroendocrine carcinoma (HGNEC) variably call the tumors Merkel cell carcinoma (MCC) or small-cell/high-grade neuroendocrine carcinoma. We studied cases of cutaneous MCC and mucosal HGNEC to better distinguish them and to better define oral cases. Study design: Twelve cutaneous … Web11 apr 2024 · A representative whole-section of each case was stained for the following SCLC subtype markers: ASCL1, NEUROD1, POU2F3, and YAP1. All samples were stained for Rb and p53 IHC to determine the clonal relationship of both components in combined SCLC and to ensure that all transcription factor-expressing cells, especially YAP1 …
Whole-Section Landscape Analysis of Molecular Subtypes
Web1 apr 2024 · 高悪性度神経内分泌癌 (HGNEC)は肺癌の中でも予後不良であり化学療法に高確率で耐性化する。申請者はHGNECはほぼYAP1陰性の神経内分泌型 (NE type) 細胞からなるが、その中にYAP1陽性のnon-NE typeが不均一に存在することを見出した。YAP1 はHippo pathway のエフェクターで様々な癌腫で増殖と薬剤抵抗性に ... WebYAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. 原文地址：. 摘要. 头颈部鳞状细胞癌（HNSCC）是世界上第六大常见癌症，患者预后较差。. 在这里，我们提出的数据表明，YAP1可能是HNSCC的主要亚型--口腔SCC（OSCC）的发病和进展的有力驱动因素 ... shane wrestler
Molecular Subtypes of High-Grade ... preview & related info
WebYAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis. YAP1 was first identified … Web1 apr 2024 · Diagnoses based on the prevailing WHO criteria, without central pathological review, of both the biopsy specimen and resection specimen from the included patients, were clustered into subgroups by applying the criteria listed in Table 1 (TC, AC, not-otherwise-specified [NOS]), high-grade NE carcinoma (HGNEC), and other. Patients with … WebDescription: Homo sapiens Yes1 associated transcriptional regulator (YAP1), transcript variant 1, mRNA. (from RefSeq NM_001130145) RefSeq Summary (NM_001130145): … shane wrestling