Multiple myeloma cast nephropathy
Web25 feb. 2024 · Multiple myeloma (MM) is the second most common hematologic malignancy that involves monoclonal immunoglobulin (Ig)-producing plasma cells. Due to its multifaceted clinical manifestations and complications, it draws attention to various medical specialties like neurology, nephrology, orthopedics, cardiology, etc. Renal failure (RF) is …
Multiple myeloma cast nephropathy
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Web29 mar. 2024 · Acute kidney injury (AKI) caused by light chain cast nephropathy (LCCN) is one of the major complications from multiple myeloma (MM). It is most commonly seen at initial MM diagnosis but can also develop later in the course of disease during relapse. WebCast nephropathy is due to the interaction and aggregation of filtered free light chains (FLCs) and Tamm- Horsfall protein (THP) causing intratubular obstruction and damage. …
Web28 ian. 2024 · Background. Light chain cast nephropathy (LCCN) is the most common renal disease caused by multiple myeloma (MM). In addition to ordinary light chain … WebSummary. Multiple myeloma is cancer of plasma cells in the bone marrow. The abnormal cells reduce the levels of healthy blood cells. Multiple myeloma causes weakening of …
WebMultiple Myeloma: Cast Nephropathy, VTE, and Neurologic Complications Multiple myeloma accounts for approximately 1% of neoplastic diseases and 13% of hematologic … Web3 mar. 2024 · Myeloma cast nephropathy (MCN) is a common cause of severe renal impairment in multiple myeloma (MM). The level of free light chain (FLC) that causes MCN varies substantially and there is...
Web30 nov. 2024 · This topic will review the treatment of kidney disease in patients with multiple myeloma or other monoclonal gammopathies, with a focus on light chain cast …
Web1 sept. 2015 · The underlying pathophysiology is complex and related to multiple mechanisms that include myeloma cast nephropathy, renal amyloidosis, … batman buff bandanaWeb12 feb. 2024 · The patient received plasmapheresis initially because the most probable diagnosis was considered to be vasculitis (it is considered the standard treatment for … terranova radno vrijemeWeb6 mar. 2024 · Also called myeloma cast nephropathy or myeloma kidney Occurs in 30 - 40% at autopsy Proteinuria consisting of light chains, which are normally filtered by … terranova polska kontaktWeb13 nov. 2024 · Myeloma cast nephropathy (CN) is the most common form of monoclonal immunoglobulin-mediated kidney disease, resulting from the precipitation of excessive amounts of monoclonal serum free light chains (sFLC) and causing around 70% of the cases of dialysis-dependent renal failure in multiple myeloma (MM)(Heher et al. 2013; … terra nova proizvodiWeb12 feb. 2024 · The patient received plasmapheresis initially because the most probable diagnosis was considered to be vasculitis (it is considered the standard treatment for small vessel vasculitis that required dialysis or had a serum creatinine over 5.8 mg/dl). With the diagnosis of cast nephropathy secondary to multiple myeloma, chemotherapy was … batman bugha ageWeb2 dec. 2016 · Multiple myeloma (MM) is often revealed by acute kidney injury (AKI) usually related to MCN. Recovery of renal function is a key prognostic factor. With novel anti-myeloma agents, HD-independence occurs in about 30% of pts with severe AKI, advocating for the use of additional strategies to rapidly remove circulating monoclonal free light … terranova plaza storesWeb30 oct. 2024 · We included 13 patients with MM or smoldering myeloma (SMM) and ESRD transplanted between 2007 and 2015, including 7 MM with cast nephropathy, 3 with MM-associated amyloid light chain amyloidosis or light chain deposition disease and 3 SMM and compared them with 65 control-matched kidney-transplanted patients. batman bugha settings