WebApr 1, 2024 · This method providing a facile access to a diverse range of highly substituted 1,3-oxathiolane-2-imines in good to excellent yields and with high Z-selectivity and excellent functional group tolerance. In addition, the established protocol can be easily scaled up to gram level in excellent yield. Furthermore, transformation of cycloadduct into ... WebNational Center for Biotechnology Information
Large-Scale Stereoselective Synthesis of 1,3-Oxathiolane …
WebNov 4, 2024 · The majority of methods traditionally involves the chemical modification of nucleoside structures. It requires the creation of artificial sugars, which is accompanied by coupling nucleobases via N-glycosylation. However, over the last three decades, efforts were made for the synthesis of 1,3-oxathiolane nucleosides by selective N-glycosylation ... WebProduct Name: 5-phenyl-1,3-oxathiolane-2-thione CAS Number: 86972-18-1 EINECS: Molecular Weight: 196.294 Molecular Formula: C9H8OS2 HS Code: Mol File: 86972-18-1.mol Synonyms: 5-phenyl-1,3-oxathiolane-2-thione Post Buying Request Now Navigation Chemical Properties Safety information and MSDS Supplier and reference price city of berea greece
Synthesis of a Novel Class of 1,3-oxathiolane Nucleoside …
WebMar 11, 2009 · The X-ray structure of major trans diastereomer of 2-phenyl-4-isobutyl-1,3-oxathiolane S,S-dioxide shows an envelope conformation with oxygen at the flap and an internal angle at sulfur of just 93 ... WebFeb 19, 2024 · A stereoselective large-scale synthetic process is described to produce 1, 3 –oxathiolane nucleoside, lamivudine (3TC). A mild, inexpensive and readily available zirconium (IV) chloride (ZrCl4 ... Weboxathiolane supply chain HIV Lamivudine (3TC, 1) and emtricitabine (FTC, 2) are essential components of widely prescribed multidrug regimens. 1 Both nucleoside analogues are high-dosage/high-demand drugs and manufactured in large volumes (>1000 MT/year). city of berea maintenance