Web12 Jun 2008 · Spongistatin 1 induces protein degradation of X-linked inhibitor of apoptosis and is able to kill XIAP-overexpressing cells. Spongistatin-induced apoptosis is driven by … Web16 Jun 1997 · Patent number: 5883120 Type: Grant Filed: Jun 16, 1997 Date of Patent: Mar 16, 1999 Assignee: Arizona Board of Regents, a body corporate, acting on behalf of …
Antineoplastic Agents 293. The Exceptional Human Cancer Cell …
Web1 May 2002 · Synthesis and Biological Evaluation of Phorboxazole Congeners Leading to the Discovery and Preparative-Scale Synthesis of (+)-Chlorophorboxazole A Possessing … Ideally, the identification of a suitable site for the installation of a linker functional group as well as the structural redesign of any acid-sensitive groups with no loss of potency would be guided by structural biological information regarding the interaction of spongistatin 1 with its receptor, but no such information is … See more Retrosynthetic disconnection by way of macrolactonization and Wittig reactions19 leads to two major fragments of approximately equal complexity, the ABCD* … See more Not knowing at the outset which of the C(17) diastereomeric aldehydes 9a and 9b would perform best in the critical fragment coupling crotylation reaction, we … See more Our synthesis of the chlorodiene-bearing EF fragment commenced with a double cross-metathesis reaction between diene 26 and tert-butyl acrylate using the … See more Wittig coupling of EF fragment 7 with aldehydes 6a–c proceeded smoothly and delivered 40a–c, in 58–63% yields (Fig. 5a). Selective deprotection of the TIPS … See more slow feeders for hay
The Spongistatins: Architecturally Complex Natural …
Web1 Jun 2009 · Enantioselective approaches to the construction of four complex building blocks of the structurally intricate marine macrolide known as spongistatin 1 are presented. The first phase of the synthetic effort relies on a practical approach to a desymmetrized, enantiomerically pure spiroketal ring system incorporating rings A and B. Concurrently, … WebSpongistatin 1 inhibits endothelial cell proliferation at 100 pM concentration, which neither cell cycle affected, nor apoptosis or cytotoxicity induced. Signaling processes that are … Web16 Jun 1997 · More particularly, this invention relates to the discovery of remarkably unexpected properties for a series of macrocyclic lactone polyethers (spongistatins) which are derived from the marine sponges Spongia sp. and Spirastrella spinispirulifera and which inhibited growth of yeasts and filamentous fungi in disk diffusion and broth macrodilution … software for home daycare business